Observe patients for any changes in BP occurring w/ postural change. Confirm use of any antihypertensive agents prior to treatment initiation. Closely monitor BP during concurrent treatment w/ antihypertensives. Reports of intraoperative floppy iris syndrome in patients currently taking or w/ history of treatment w/ α1-blockers. Patients w/ orthostatic hypotension. Patients w/ past history of sulfonamide hypersensitivity. May impair ability to drive or operate machinery. Patients w/ severe renal or hepatic impairment. Elderly.
Orthostatic hypotension w/ antihypertensives. Enhanced vasodilatory hypotensive action of phosphodiesterase-5 inhibitors eg, sildenafil citrate, vardenafil HCl hydrate. Significant increase in exposure when co-administered w/ a strong CYP3A4 inhibitor eg, ketoconazole, itraconazole, ritonavir, atazanavir sulfate, indinavir sulfate, nelfinavir, saquinavir mesylate, clarithromycin, telithromycin. Do not use in combination w/ strong CYP3A4 inhibitors in patients known to be CYP2D6 poor metabolizers.
Sign Out
